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Ultrafiltration Systems - List of Manufacturers, Suppliers, Companies and Products

Ultrafiltration Systems Product List

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Ultrafiltration TFF Minimate EVO System

"Streamlining lab-scale concentration, desalting, and buffer exchange processes" *Demo units available for loan!*

Tangential flow filtration (TFF) is a filtration method that applies a constant pressure to the membrane side by flowing liquid samples parallel to the membrane surface, allowing solutes and small molecules to pass through the membrane. Compared to conventional direct flow filtration, TFF is less prone to filter clogging because it is continuously perfused parallel to the membrane surface, enabling efficient and large-capacity ultrafiltration. The Minimate EVO TFF system is suitable for large-scale protein and nucleic acid purification and is equipped with Omega membranes that have a wide range of molecular weight cut-offs (MWCO) from 1K to 1000K. It is also suitable for applications that require the purification of exosomes, which are extracellular nano-vesicles, from large volumes of cell culture media. It has been reported that TFF methods have a higher recovery rate of exosomes from cell culture media compared to ultracentrifugation [1], and there are also proven results with Minimate [2]. If you are considering large-volume sample ultrafiltration, please feel free to contact us. [1] Busatto S., et al., Cells, 7, 273-283 [2] Sung SE., et al., Int J Mol Sci, 22, 2889-2900

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  • Other filtration and separation equipment

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Large-scale exosome purification utilizing tangential flow filtration.

Ideal for sample volumes of 1-100 L! We introduce products that support large-capacity ultrafiltration with TFF!

Exosome purification utilizes various ultracentrifugation methods with established size fractionation protocols. However, due to the nature of ultracentrifugation, there is a challenge in increasing the amount of sample that can be processed. Cytiva offers a "TFF system" that combines flow systems and tangential flow filtration, which is introduced as one solution to this challenge. Additionally, there are examples of its use for the purification and concentration of exosomes from cultured cells. To perform exosome purification from large-volume samples derived from cultured cell lines, we provide products suitable for each step, including the removal of cells and debris, the removal of microvesicles and other cellular vesicles, and the purification of exosomes. 1. Debris removal from cell culture media: Supracap 50, 100 depth filter capsules 2. Removal of microvesicles and other cellular vesicles: VacuCap bottle-top filters 3. Exosome purification: Minimate EVO TFF system [1] Jong et al., Nat Commun. 2020. 11. 1113.

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  • Other cell research

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MiniLab Tangential Flow Ultrafiltration System for Laboratory Use

The only single-use supplier that can manufacture everything from materials to final products in-house!

To better support the research and development processes of pharmaceutical companies, we have developed and designed the small TFF (Tangential Flow Filtration) ultrafiltration system, Minilab. We focus on solving many of the issues encountered in research and development testing. The Minilab TFF system features free combinations and flexible matching, allowing it to adapt to various complex usage environments of our customers.

  • Other physicochemical equipment

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